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(S)-2-Amino-3-(3-(Methylsulfonyl)Phenyl)Propanoic Acid

Basic Information

  • CAS Number 1270093-99-6
  • Molecular Formula C10H13NO4S
  • Molucular Weight 243.28
  • Package: 500g/bag, 1kg/bag, 5kg/bag, 10kg/bag, 25kg/drum, or as per customer requirements
  • Storage seale in a light-proof container and store in a cool (2–8℃), dry and well-ventilated place。
  • Retest Period Two Years

product Description

(S)-2-Amino-3-(3-(Methylsulfonyl)Phenyl)Propanoic Acid is an important chiral amino acid derivative and a key organic intermediate for the synthesis of drugs containing methylsulfonyl groups, with a CAS registry number of 145901-29-5, a molecular formula of C₁₀H₁₅NO₄S, and a molecular weight of 245.30. It is typically a white to off-white crystalline powder with good stability and can be used in the synthesis of Lifitegrast.

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Its key physicochemical properties are as follows: it is soluble in polar organic solvents such as methanol, ethanol and N,N-dimethylformamide, soluble in water (water solubility enhanced by amino acid structure and sulfonyl group), and insoluble in non-polar solvents like petroleum ether and n-hexane. The melting point ranges from 228–232℃, the product purity is generally ≥98% (determined by HPLC), and the water content is ≤0.5%.

In terms of safety and storage, this compound is slightly irritating to the skin, respiratory tract and eyes. Protective gloves, goggles and masks should be worn during operation to avoid direct contact and inhalation; if contact occurs accidentally, rinse the affected area with plenty of water immediately. It should be sealed in a light-proof container and stored in a cool (2–8℃), dry and well-ventilated place, away from strong oxidants, strong acids and alkalis, and avoid high temperature and humid environments to prevent oxidation, degradation or racemization, ensuring storage stability and chiral purity.

product Specification

Item

Unit

Specification

Appearance

 

a white to off-white crystalline powder

Solubility

 

soluble in polar organic solvents such as methanol, ethanol and N,N-dimethylformamide, soluble in water (water solubility enhanced by amino acid structure and sulfonyl group), and insoluble in non-polar solvents like petroleum ether and n-hexane.

Melting point

228–232

Identification

 

infrared spectroscopy + HPLC retention time

Other impurities

%

≤0.1 

Related Substances - Total Impurities

%

≤2.0

Main peak purity

%

≥98.0

Water content

%

≤0.5

Storage

 

seale in a light-proof container and store in a cool (2–8℃), dry and well-ventilated place.

 

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