(R)-Cyclohex-3-enylamine Hydrochloride - Quality Product from China Suppliers and Reliable Factory
Basic Information
Product Description
(R)-3-Cyclohexen-1-amine hydrochloride, with a dedicated chiral monomer CAS No. 1350767-92-8 and racemate CAS No. 4044-02-8, has the molecular formula C₆H₁₂ClN and a molecular weight of 133.62. It is a high-value chiral aliphatic amine hydrochloride intermediate, featuring exclusive (R)-configuration specificity and stable hydrochloride form, serving as a key chiral building block in fine chemical synthesis and chiral pharmaceutical R&D.
This intermediate is based on a cyclohexene skeleton with a carbon-carbon double bond at the 3-position of the ring. The 1-position carbon atom acts as the chiral center, linked to a protonated amino group (-NH₃⁺Cl⁻). The fixed (R)-configuration endows it with a unique spatial structure, which can accurately meet the configuration requirements of downstream synthesis. Compared with free amine, its hydrochloride form has higher stability with resistance to oxidation, and good solubility in polar solvents such as water, methanol and ethanol. It can significantly simplify feeding, reaction and post-treatment operations in the synthesis process, improving process compatibility.
In terms of applications, first, as a core intermediate for chiral active pharmaceutical ingredient (API) synthesis, it is widely used in the R&D and production of nervous system drugs, anti-infective drugs and other categories. The (R)-configuration directly determines the binding efficiency between drugs and targets, ensuring efficacy exertion and reducing side effects caused by non-target configurations. Second, it can be used as a precursor for preparing chiral amine ligands, matching transition metal catalysts to participate in asymmetric hydrogenation, addition and other reactions, greatly improving the chiral selectivity and purity of downstream products.
Industrial Application & Storage: For industrial application, this intermediate has strict purity requirements, generally requiring chiral purity (ee value) ≥ 98%. For storage, it should be sealed and placed in a dry, cool and well-ventilated environment to avoid moisture absorption, caking or degradation, so as to maintain the stability of product quality.
Product Specification
| Item | Unit | Specification |
|---|---|---|
| Appearance | - | white to off-white |
| Solubility | - | soluble in polar solvents such as water, methanol and ethanol. |
| Identification | - | infrared spectroscopy + HPLC retention time |
| Other impurities | % | ≤0.1 |
| Related Substances - Total Impurities | % | ≤2.0 |
| Main peak purity | % | ≥98.0 |
| Chiral Purity | % | ≥98.0 |
| Storage | - | sealed and placed in a dry, cool and well-ventilated environment |