product Description
N-methyl-6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-amine (CAS No. 290297-25-5) is a high-value pharmaceutical intermediate with the molecular formula C₁₈H₂₄N₄ and a molecular weight of 296.41 g/mol. It presents as a white to pale yellow crystalline powder and maintains stability when stored in a sealed, dry container at room temperature, facilitating industrial storage and transportation.
Its key physicochemical properties include a predicted density of 1.12±0.06 g/cm³, a predicted pKa of 8.2±0.2, and a LogP value of 2.85. It is soluble in organic solvents such as dimethyl sulfoxide (DMSO), N,N-dimethylformamide (DMF) and methanol, providing a fundamental basis for its separation, purification, and reaction process design in pharmaceutical synthesis.
As a core pharmaceutical intermediate, it is mainly applied in the synthesis of Netupitant, a potent NK1 receptor antagonist widely used in the treatment of chemotherapy-induced nausea and vomiting (CINV), which is usually combined with Palonosetron to enhance antiemetic efficacy. It serves as a key structural building block in the synthetic route of Netupitant, and also supports the R&D of other piperazine-containing pyridine derivatives for pharmaceutical applications.
product Specification
|
Item |
Unit |
Specification |
|
Appearance |
|
white to pale yellow crystalline powder |
|
Solubility |
|
soluble in organic solvents such as dimethyl sulfoxide (DMSO), N,N-dimethylformamide (DMF) and methanol |
|
Other impurities |
% |
≤0.5 |
|
Related Substances - Total Impurities |
% |
≤2.0 |
|
Main peak purity |
% |
≥98.00 |
|
Moisture |
% |
≤0.5 |
|
Storage |
|
sealed, dry container at room temperature |
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