Intermediates

01

N-methyl-6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-amine

02

2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid

03

tert-butyl ((1R,3R,4R)-3-hydroxy-4-mercaptocyclohexyl)carbamate

04

(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(tosyloxy)acetate

05

N-((1R,3R,6S)-7-oxabicyclo[4.1.0]heptan-3-yl)-2,2,2-trifluoroacetamide

06

tert-butyl ((1R,3R,6S)-7-oxabicyclo[4.1.0]heptan-3-yl)carbamate

07

(R)-Cyclohex-3-enylamine hydrochloride

08

benzyl (S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoate

09

2-(tert-butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

10

(S)-2-Amino-3-(3-(Methylsulfonyl)Phenyl)Propanoic Acid

11

benzofuran-6-carboxylic acid

12

6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride