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High-Quality Uridine Active Pharmaceutical Ingredient from China - Trusted Suppliers and Factory for Your Needs
Basic Information
Product Description
Uridine is a glycosylated pyrimidine-analog. It consists of uracil attached to a ribose ring — more precisely a ribofuranose — through a β-N₁-glycosidic bond. Among the five standard nucleosides that constitute nucleic acids, uridine holds a significant position.
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The five standard nucleosides are commonly abbreviated to their one-letter codes: U for uridine, A for adenosine, T for thymidine, C for cytidine, and G for guanosine.
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Thymidine is more frequently written as 'dT', where the 'd' stands for 'deoxy'. This is because thymidine contains a 2'-deoxyribofuranose moiety, in contrast to the ribofuranose ring present in uridine.
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Thymidine is a component of deoxyribonucleic acid (DNA), while uridine is found in ribonucleic acid (RNA). The remaining three nucleosides (adenosine, cytidine, and guanosine) can be present in both RNA and DNA — represented as A, C, G in RNA and dA, dC, dG in DNA.
Product Specification
| Items | Specification |
|---|---|
| Description | White or almost white crystalline powder |
| Identification |
The largest absorption at 262±2nm wavelength and the minimum absorption at 231±2nm A250/A260 = 0.70–0.80 | A280/A260 = 0.32–0.38 |
| Clarity and Color of Solution | Clarify |
| Loss on Drying | ≤ 0.5% |
| Rotation | +6.0° – +10.0° |
| Ignition Residue | ≤ 0.1% |
| Purity (HPLC) | ≥ 98.0% |
| Contents (Dry Basis) | 98.0% – 102.0% |
Applications
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Uridine has multiple applications in the medical field. It can be used as a medicine to treat various conditions such as macrocytic anemia, liver diseases, cerebrovascular diseases, and cardiovascular diseases.
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It serves as the main raw material for the production of several important drugs, including fluorouracil (S-FC), a well-known anti-cancer drug.
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It is also involved in the synthesis of deoxyribonucleoside, idoxuridine (IDUR), bromodeoxyuridine (BUDR), and fluorodeoxyuridine (FUDR), all of which have significant medical uses in different therapeutic areas.
Frequently Asked Questions (FAQ)
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What is uridine and what is its chemical structure?
Uridine is a glycosylated pyrimidine-analog composed of uracil attached to a ribofuranose ring through a β-N₁-glycosidic bond. It is one of the five standard nucleosides that make up nucleic acids and is naturally found in ribonucleic acid (RNA).
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What is the difference between uridine and thymidine?
Uridine contains a ribofuranose ring and is found in RNA, while thymidine (abbreviated as 'dT') contains a 2'-deoxyribofuranose moiety and is a component of DNA. The 'd' prefix in 'dT' stands for 'deoxy', indicating the absence of an oxygen atom on the 2' carbon.
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What is the purity specification of this uridine product?
This uridine product has a minimum purity of ≥98.0% as determined by HPLC, and the content on a dry basis ranges from 98.0% to 102.0%. It appears as a white or almost white crystalline powder.
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What medical conditions can uridine be used to treat?
Uridine can be used as a therapeutic agent for conditions including macrocytic anemia, liver diseases, cerebrovascular diseases, and cardiovascular diseases. It is also widely used as a key raw material in pharmaceutical manufacturing.
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Which important drugs are synthesized from uridine?
Uridine is a critical starting material for the synthesis of several pharmaceutical compounds, including fluorouracil (S-FC) — a well-known anti-cancer agent — as well as idoxuridine (IDUR), bromodeoxyuridine (BUDR), fluorodeoxyuridine (FUDR), and various deoxyribonucleoside derivatives.
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How is uridine identified and what are its key spectroscopic properties?
Uridine is identified by its UV absorption profile: the largest absorption occurs at 262±2 nm and the minimum absorption at 231±2 nm. The absorbance ratios A250/A260 = 0.70–0.80 and A280/A260 = 0.32–0.38 are used as identification criteria. Its optical rotation is +6.0° to +10.0°.