China Uridine API Suppliers - High-Quality Manufacturing at Our Factory
Basic Information
Uridine is a glycosylated pyrimidine-analog consisting of uracil attached to a ribose ring (ribofuranose) through a β-N₁-glycosidic bond. It is one of the five standard nucleosides that constitute nucleic acids.
Among the five standard nucleosides, uridine holds a significant position. The other four are adenosine, thymidine, cytidine, and guanosine — commonly abbreviated to their one-letter codes: U for uridine, A for adenosine, T for thymidine, C for cytidine, and G for guanosine.
Thymidine is more frequently written as 'dT', where 'd' stands for 'deoxy'. It contains a 2'-deoxyribofuranose moiety, in contrast to the ribofuranose ring present in uridine. Thymidine is a component of DNA, while uridine is found in RNA. The remaining three nucleosides (adenosine, cytidine, and guanosine) can be present in both RNA and DNA — represented as A, C, G in RNA and dA, dC, dG in DNA.
| Items | Specification |
| Description | White or almost white crystalline powder |
| Identification | The largest absorption at 262±2nm wavelength and the minimum absorption at 231±2nm A250/A260 = 0.70–0.80 | A280/A260 = 0.32–0.38 |
| Clarity and Color of Solution | Clarify |
| Loss on Drying | ≤ 0.5% |
| Rotation | +6.0° – +10.0° |
| Ignition Residue | ≤ 0.1% |
| Purity (HPLC) | ≥ 98.0% |
| Contents (Dry Basis) | 98.0% – 102.0% |
Uridine has multiple applications in the medical field. It can be used as a medicine to treat various conditions such as macrocytic anemia, liver diseases, cerebrovascular diseases, and cardiovascular diseases.
Moreover, it serves as the main raw material for the production of several important drugs:
- 💊Fluorouracil (S-FC) — a well-known anti-cancer drug
- 💊Deoxyribonucleoside synthesis
- 💊Idoxuridine (IDUR) — antiviral therapeutic use
- 💊Bromodeoxyuridine (BUDR) — used in cell proliferation studies
- 💊Fluorodeoxyuridine (FUDR) — significant medical uses in different therapeutic areas
