China Suppliers of Benzyl (S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoate from Factory Direct
Basic Information
Benzyl (S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoate is an important chiral amino acid benzyl ester derivative, containing a methylsulfonyl functional group and a benzyl ester protecting structure. As a key organic intermediate for drug synthesis, it can be used in the synthesis of Lifitegrast, with a CAS registry number of 1194550-59-8, a molecular formula of C₁₇H₁₉NO₄S, and a molecular weight of 369.86. It is typically a white to off-white crystalline powder with good stability, suitable for drug synthesis scenarios.
Its key physicochemical properties are as follows: it is soluble in polar organic solvents such as methanol, ethanol, dichloromethane and ethyl acetate, slightly soluble in water, and insoluble in non-polar solvents like petroleum ether and n-hexane. The melting point ranges from 128–132℃, the product purity is generally ≥98% (determined by HPLC), and the water content is ≤0.5%. The benzyl ester group in the molecule can realize selective protection and deprotection of the carboxyl group, facilitating subsequent functional group modification, while the amino group can participate in condensation, amidation and other reactions, adapting to subsequent drug synthesis processes.
This compound is slightly irritating to the skin, respiratory tract and eyes. Protective gloves, goggles and masks should be worn during operation to avoid direct contact and inhalation; if contact occurs accidentally, rinse the affected area with plenty of water immediately.
- Seal in a light-proof container and store in a cool (2–8℃), dry and well-ventilated place.
- Keep away from strong oxidants, strong acids and alkalis.
- Avoid high temperatures and humid environments to prevent oxidation, degradation or racemization.
- Avoid benzyl ester group hydrolysis to ensure storage stability and chiral purity.
| Item | Unit | Specification |
|---|---|---|
| Appearance | A white to off-white crystalline powder | |
| Solubility | Soluble in polar organic solvents such as methanol, ethanol, dichloromethane and ethyl acetate; slightly soluble in water; insoluble in non-polar solvents like petroleum ether and n-hexane. | |
| Melting Point | ℃ | 128–132 |
| Identification | Infrared spectroscopy + HPLC retention time | |
| Other Impurities | % | ≤ 0.1 |
| Related Substances – Total Impurities | % | ≤ 2.0 |
| Main Peak Purity | % | ≥ 98.0 ✔ High Purity |
| Water Content | % | ≤ 0.5 |
| Storage | Sealed in a light-proof container and stored in a cool (2–8℃), dry and well-ventilated place. |