Benzofuran-6-Carboxylic Acid: Top China Suppliers and Factory for High-Quality Chemical Products
Basic Information
Benzofuran-6-carboxylic acid is an important benzofuran-based aromatic carboxylic acid derivative and a key organic intermediate for the synthesis of pharmaceuticals, dyes and functional materials, which can be used in the synthesis of Lifitegrast. It has a CAS registry number of 77095-51-3, a molecular formula of C₉H₆O₃, and a molecular weight of 162.14. Typically appearing as a white to off-white crystalline powder, it has good stability. Its molecule contains a benzofuran skeleton and a carboxyl group, possessing both the bioactive potential of heterocyclic compounds and the reactivity of carboxylic acids, serving as a common building block in fine chemicals and pharmaceutical R&D.
Its key physicochemical properties are as follows: it is soluble in polar organic solvents such as methanol, ethanol, dichloromethane and ethyl acetate, slightly soluble in water, and insoluble in non-polar solvents like petroleum ether and n-hexane. The melting point ranges from 180–184℃, the product purity is generally ≥98% (determined by HPLC), and the water content is ≤0.5%. The benzofuran skeleton in the molecular structure endows it with unique electronic effects and lipophilicity, and the carboxyl group can undergo condensation, amidation, esterification and other reactions, adapting to diverse subsequent synthetic reactions and providing support for constructing complex functional molecules.
Safety & Storage: This compound is slightly irritating to the skin, respiratory tract and eyes. Protective gloves, goggles and masks should be worn during operation to avoid direct contact and inhalation; if contact occurs accidentally, rinse the affected area with plenty of water immediately. It should be sealed in a light-proof container and stored in a cool (2–8℃), dry and well-ventilated place, away from strong oxidants and strong bases (to avoid carboxyl decarboxylation), and avoid high temperature and humid environments to prevent oxidation, degradation and other reactions, ensuring storage stability.
| Item | Unit | Specification |
|---|---|---|
| Appearance | A white to off-white crystalline powder | |
| Solubility | Soluble in polar organic solvents such as methanol, ethanol, dichloromethane and ethyl acetate; slightly soluble in water; insoluble in non-polar solvents like petroleum ether and n-hexane. | |
| Melting Point | ℃ | 180–184 |
| Identification | Infrared spectroscopy + HPLC retention time | |
| Other Impurities | % | ≤ 0.1 |
| Related Substances – Total Impurities | % | ≤ 2.0 |
| Main Peak Purity | % | ≥ 98.0 |
| Water Content | % | ≤ 0.5 |
| Storage | Sealed in a light-proof container; store in a cool (2–8℃), dry and well-ventilated place. |