5-methoxy-2-(2H-1,2,3-triazol-2-yl)benzoic acid

5-methoxy-2-(2H-1,2,3-triazol-2-yl)benzoic acid (Molecular Formula: C₁₀H₉N₃O₃; CAS No.: 1293284-55-5) is a benzoic acid derivative with a chemical structure characterized by a methoxy group (-OCH₃) substituted at the 5-position and a 2H-1,2,3-triazol-2-yl group substituted at the 2-position of the benzene ring. Under ambient temperature and pressure, it exists as a white to brown solid powder, which is almost insoluble in water but soluble in alcoholic organic solvents.

Notably, this compound serves as a key intermediate for Daridorexant, a novel dual orexin receptor antagonist clinically indicated for the treatment of adult insomnia. Its quality is subject to strict control specifications as follows: (1) Compliance of appearance is verified in accordance with General Notice 15, Part IV of the Chinese Pharmacopoeia (ChP) 2020 Edition; (2) Related substances and purity are determined by High Performance Liquid Chromatography (HPLC) pursuant to General Chapter 0512, Part IV of ChP 2020 Edition, with the following limits: impurity at relative retention time (RRT) 0.72 ≤ 0.3%, impurity GE028B-3 ≤ 0.3%, individual unknown impurity ≤ 0.5%, total impurities ≤ 2.0%, and purity ≥ 98.0%; (3) Moisture content is controlled to not exceed 0.5% in line with General Chapter 0832, Part IV of ChP 2020 Edition.

The recommended storage condition for this compound is sealed preservation at room temperature, with a retest period of 24 months.