product Description
4-Chloro-3-methylbenzene-1,2-diamine hydrochloride (C₇H₁₀Cl₂N₂). This product is a white to off-white crystalline powder; odorless; almost non-hygroscopic. It is slightly soluble in methanol, sparingly soluble in ethanol, almost insoluble in water, and soluble in N,N-dimethylformamide. The product is stable under dry and light-protected conditions, and susceptible to oxidative deterioration when exposed to strong oxidants.
Spectral and chromatographic characteristics and quality control: ① ¹H NMR (DMSO-d₆, 400 MHz) shows a methyl singlet at δ 2.25 in the high-field region, and aromatic proton signals at δ 6.85–7.20; ② HPLC (C18 column, mobile phase: methanol-0.05 mol/L potassium dihydrogen phosphate solution (30:70, v/v), pH adjusted to 3.0 with phosphoric acid, detection wavelength: 254 nm, flow rate: 1.0 mL/min, column temperature: 30 °C, injection volume: 20 μL): The retention time of the main peak is about 8.5 min; quality control requirements: main peak purity ≥ 99%, dechlorinated impurity ≤ 0.1%, other impurities ≤ 0.2%.
This product can be prepared via catalytic hydrogenation and is mainly used as a key intermediate for the anti-insomnia drug Daridorexant..
Applications
√It serves as a key pharmaceutical intermediate for the insomnia treatment Daridorexant .
√It can be used to prepare polyimide materials, which have excellent thermal stability and solubility in organic solvents. These materials are widely applied in high-end fields like electronics and aviation.
√As an organic synthesis building block, it is used to produce dyes and pigments (leveraging its aromatic structure and reactivity to form stable colored compounds); It can also be utilized in the synthesis of agrochemicals and specialty fine chemicals.
product Specification
|
Item |
Unit |
Specification |
|
Main peak purity |
% |
99.00 min |
|
Moisture |
% |
0.50 max |
|
Dechlorinated impurity |
% |
0.1 max |
|
Other impurities |
% |
0.2 max |
|
Solubility |
|
slightly soluble in methanol, sparingly soluble in ethanol, almost insoluble in water, and soluble in N,N-dimethylformamide |
|
Appearance |
|
white to off-white ,solid |
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